|
KMID : 0605820140210030174
|
|
Korean Journal of Pediatric Infectious Diseases
2014 Volume.21 No. 3 p.174 ~ p.180
|
|
|
Clinical and Epidemiological Study of 1,165 Hospitalized Cases of Rotaviral Gastroenteritis Before and After the Introduction of Rotavirus Vaccine, 2006-2013
|
|
Sohn Tae-Young
Lee Chan-Jae
Kim Yoon-Joo
Kang Min-Jae
Kim Sung-Hye
Lee So-Yeon
Lee Dae-Hyoung
Lee Hae-Ran
Kim Kwang-Nam
|
|
|
Abstract
|
|
|
Purpose : This study was performed to assess the clinical and epidemiological changes after the introduction of rotavirus vaccine in Korea, as well as to determine the efficacy of rotavirus vaccine among hospitalized rotaviral gastroenteritis patients over the past two years.
Methods : We analyzed yearly and seasonal patterns of 1,165 inpatients who were hospitalized for rotaviral gastroenteritis under the age of 5 years between 2006 and 2013. We also conducted a survey among 460 gastroenteritis patients who were hospitalized between 2012 and 2013 regarding the rotavirus vaccination and the symptoms of gastroenteritis. Among those individuals surveyed, clinical indices were analyzed for 125 patients who were tested positive for the rotavirus antigen.
Results : The incidence of Rotaviral gastroenteritis have decreased significantly by year 2010. After the introduction and widespread dissemination of the rotavirus vaccine, the onset of the disease and the seasonal peak have been delayed. Overall, the vaccinated group showed a lower rate of positivity than the unvaccinated group. Among the hospitalized rotaviral gastroenteritis patients, the vaccinated group had a shorter hospitalization period, less severe clinical symptoms of gastroenteritis, and better laboratory test results.
Conclusions : After introduction of the rotavirus vaccine in Korea, there were two main trends observed: 1) the overall level of disease incidence was reduced; 2) the severity of rotaviral gastroenteritis cases also decreased. Based on this data, more children should receive vaccination in order to prevent the rotavirus infection and decrease the severity of rotaviral gastroenteritis.
|
|
|
KEYWORD
|
|
|
Rotavirus, Gastroenteritis, Vaccine, Epidemiology
|
|
|
FullTexts / Linksout information
|
|
|
|
|
|
Listed journal information
|
|
 
|
|